Location: Downtown Columbus, OH
I'm assuming those cars below the giant ad are part of the whole thing, but like the site the photo links to, I kinda want them to be innocent bystanders' cars.
From my visit to Columbus last year, I believe this is the building that had a giant poster of a young Fabio pictured in a romance novel sort of way. On the other tower was the old Fabio. Here's the video.
The Nationwide "Life Comes at You Fast" campaign is pretty awesomely clever.